Papers related with bacterial GAPDH

  • Alves, J., et al., A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice. PLoS One, 2015. 10(12): p. e0144196.

  • Oliveira, L., et al., Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages. PLoS One, 2012. 7(1): p. e29963.

  • Madureira, P., et al., Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment. PLoS Pathog, 2011. 7(11): p. e1002363.

  • Madureira, P., et al., Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein. J Immunol, 2007. 178(3): p. 1379-87.

Master Thesis

  • Tiago Pereira Rodrigues. Study the accessibility of IL-10 locus in a murine model of Neonatal Sepsis. MSc Thesis in Bioengineering, 2017. FEUP, University of Porto.

  • Cristiana Andreia Pereira Nogueira. Evaluation of the efficacy of a peptide-based vaccine (PNV1) against multi-resistant gram-negative bacteria in a neonatal mice model. MSc Thesis in Bioengineering, 2017. FEUP, University of Porto.

  • Filipa Gláucia Rodrigues Lemos. Study of the cellular and molecular mechanism associated with neonatal susceptibility to bacterial infections. MSc Thesis in Biochemistry, 2016. FCUP, University of Porto.


  • Pedro Madureira & Paula Ferreira (2015). Vaccine for Immunocompromised Hosts. WO2015/189422.

  • Pedro Madureira (2020). Immunogenic compositions. European Patent Application No. 20398008.1

Oral Presentations in Scientific Meetings (As invited speaker)

  • Madureira P. Bacterial GAPDH as a target to prevent bacterial infections. ECCMID. April 2022. Lisbon, Portugal.

  • Madureira P. Development of novel anti-bacterial immunotherapies. World Vaccine and Immunotherapy Congress. December 2020. San Francisco, USA (virtual event)

  • Madureira P. Development of a virulence-targeted vaccine to prevent infections caused by MDR bacteria. 19th World Vaccine Congress. October 2018. Lisbon, Portugal.

  • Madureira P. Anti-bacterial Immunotherapies. 15th World Vaccine Congress. November 2015. Madrid, Spain.

  • Madureira P. Influence of the intestinal flora on the development of gut-associated immune responses. XIX NEDAI Annual Meeting. April 2013. Vila Moura, Algarve, Portugal.

  • Madureira P. Vaccine against GBS infection. i-techpartner Healthcare Biotech Forum Rome. March 2009. Rome, Italy.

Oral Presentations in Scientific Meetings With Referees

  • M Vieira, L Curado, A Marques, F Lemos, C Teixeira, A Fidalgo, C Nogueira, T Rodrigues, P Ferreira & P Madureira. “Antibody-mediated neutralization of a conserved extracellular immunomodulatory protein prevents neonatal sepsis caused by multidrug-resistant bacteria”. XLIII SPI Annual Meeting. June 2017. Porto, Portugal.

  • P Melo, EB Andrade, J Alves, A Ribeiro, P Ferreira and P Madureira. “Targeting Bacterial GAPDH to Prevent Neonatal Sepsis”. XL SPI Annual Meeting. October 2014. Lisboa, Portugal.